"James Murdoch, the younger son of media mogul Rupert Murdoch, has resigned from the board of News Corporation citing "disagreements over editorial content".
In a filing to US regulators, he said he also disagreed with some "strategic decisions" made by the company.
The exact nature of the disagreements was not detailed.
But Mr Murdoch has previously criticised News Corp outlets, which include the Wall Street Journal, for climate change coverage.
In recent years James Murdoch has also found himself at odds – politically – with his father, BBC North America correspondent David Willis says.
Whilst Murdoch Senior has pledged support for Donald Trump, James Murdoch has reportedly contributed hundreds of thousands of dollars to the campaign of Mr Trump's Democratic rival, Joe Biden.
James Murdoch's departure from News Corp would, our correspondent says, appear to grant even more influence to his brother Lachlan who is generally thought to share his father's more conservative views.
Rupert, News Corp's executive chairman, and Lachlan, co-chairman, wished James well in a joint statement.
"We're grateful to James for his many years of service to the company," the statement said. "We wish him the very best in his future endeavours."" BBC
I watch a lot of TeeVee news on all the major networks including the two Foxnews channels.
It has become apparent to me over the last year or so that there is an internal ideology contest at Fox between the hard core conservatives like Dobbs. Carlson, Mark Levin, Bartiromo, Degan McDowell, etc. and a much more liberal set of people like Chris Wallace, Cavuto and the newer reporters at the White House. I expect that the departure of James Murdoch will result in more uniformly conservative reporting and commentary on Fox. I say that presuming that James Murdoch was a major force in trying to push Foxnews toward the left.
I am surprised that Murdoch pere sent his son to Harvard. pl