“One-time treatment generates new neurons, eliminates Parkinson’s disease in mice” Science Daily

Parkinson

"Several years ago, a postdoctoral researcher working in Fu's lab was taking that approach, using a technique called siRNA to silence the PTB gene in connective tissue cells known as fibroblasts. But it's a tedious process that needs to be performed over and over. He got tired of it and convinced Fu they should use a different technique to create a stable cell line that's permanently lacking PTB. At first, the postdoc complained about that too, because it made the cells grow so slowly.

But then he noticed something odd after a couple of weeks — there were very few fibroblasts left. Almost the whole dish was instead filled with neurons.

In this serendipitous way, the team discovered that inhibiting or deleting just a single gene, the gene that encodes PTB, transforms several types of mouse cells directly into neurons."  Science Daily

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Does this have some relevance to approaches to treatment of senile dementia and Alzheimer's?  pl

https://www.sciencedaily.com/releases/2020/06/200625102540.htm

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6 Responses to “One-time treatment generates new neurons, eliminates Parkinson’s disease in mice” Science Daily

  1. Avatar Rick Merlotti says:

    As someone with Parkinson’s, this is very heartening. Tho I don’t expect this breakthrough or any other will save me from this scourge, may future generations reap the benefits of science applied to the general welfare of all people.

  2. Avatar Joseph Chaisson says:

    Very serious progress has recently been made on containing/reversing dementia. This work has been by a team led by Dale Bredesen. A recent paper presented results for 100 patients teated by several teams of practitioners. The worst outcome for these patients was no further losses. What is interesting is that a wide body of relatively recent research has finally figured out what causes alzheimers dementia and it is not what the alzheimers community had been assuming for decades. I had all of the doctors I deal with, including my medicare PCP, review Bredesen’s work and treatment protocol and they all agree this is solid and game changing.
    A good introductory presentation by Bredesen is at https://grandrounds.ifm.org/21st-century-medicine-and-the

  3. Avatar Nancy Tunick says:

    I am 57 and diagnosed in June 2009. I had a very long list of symptoms, some of which were. Keeping right arm close to my side while walking, tremors in right hand, numbed toes on right foot, drooling out right side of mouth, over all body aches and pain, trouble moving in bed, dry skin, hair falling out, urinary incontinence, fecal incontinence, slurred words, falling, speaking softly, tiredness, aggravation and irritation, weepy and crying a lot, loss of strength.My neurologist advised me to try natural treatments and introduced me to RHG Parkinsons Disease formula, I read alot of positive reviews from other patients who used the treatment and i immediately started on the treatment. I had great improvement and relief with this treatment, total decline of symptoms. Great improvement with speech, co-ordination, balance, muscle, mood etc, I gained back my life with this treatment and can never be thankful enough. Visit ww w. richherbalgardens .c om

  4. Avatar Babak makkinejad says:

    Col. Lang
    This breif in the May 28, 2020 of Cell magazine
    https://www.cell.com/cell/fulltext/S0092-8674(20)30556-0
    indicates, as far as I understand it, that, in principle, an analogous approach could be applied to the removal of PTB gene, or editing out sufficient scetion of it to silence it.
    The applixation to cancer took 8 years, and I expect similar rates elsewhere.
    But I am not an specialist.

  5. Avatar JJackson says:

    The Cell paper discussed, here and a follow on paper in Nature, are discussed by two neuroscientist, an MD/neuroscientist and a virologist in the Zoom discussion at the link.
    https://www.microbe.tv/twin/twin-8/

  6. Avatar Wyatt Hunter says:

    My husband is 54 and has had Parkinson’s for around 3-4 years. It is a debilitating disease that only gets worse and needs some serious funding to find out 1 because the cure is out there. What causes it and 2. some better treatment for it which multivitamincare .org have the guaranteed cure for PD. He takes over 8 weeks treatment from Multivitamin care formula that finally cure him,as there is no-one available to help unless you have $4,000.00 per week to pay for a Nurse, but with this herbal system you can get rid of your Parkinson effectively ,he had tremors for several years and was gradually becoming worse before we found PD supplement from Multivitamincare that was able to get rid of my husband disease and alleviate all symptoms within the short period of his usage.,they have the best medication for PD.

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